MENU
AUG 30, 2016 8:00 AM PDT

Endoderm Progenitors in Health and Disease

Speaker
  • Professor, Chair of Stem Cell Sciences, Program Leader, Stem Cells Australia, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Florey Neuroscience and Mental
    BIOGRAPHY

Abstract
Using human pluripotent stem cells as a screening platform, we have identified a novel cell surface maker that identifies foregut endoderm progenitors in pancreas and liver.  We have shown that   cells of the biliary reaction, a regenerative response to liver damage, premalignant and pancreatic ductal adenocarcinoma cells, and the columnar epithelium of Barrett’s Oesophagus, a preneoplastic precursor of oesophageal carcinoma, all express this antigen on their surface.  The antigen is expressed in liver and pancreas during development, and  is also found in the serum of patients with pancreatic or liver cancer.  Cell surface antigens expressed on fetal stem or progenitors cells provide biomarkers of tissue regenerative processes, and can be used to monitor progression neoplasia if repair processes fail to resolve the underlying pathology.
 

Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
NOV 09, 2021 11:00 AM PST
C.E. CREDITS
NOV 09, 2021 11:00 AM PST
Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
JUN 24, 2021 10:00 AM PDT
C.E. CREDITS
JUN 24, 2021 10:00 AM PDT
Date: June 24, 2021 Time: 10:00am PDT The Chan Zuckerberg Initiative (CZI) was founded to help solve some of society’s toughest challenges— from eradicating disease and improving...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
Loading Comments...
Show Resources