mouse monoclonal IgG1; Bcr Antibody (G6) is an IgG1 κ mouse monoclonal Bcr antibody that detects Bcr/Abl p190 and Bcr/Abl p210 fusion proteins of mouse, rat and human origin by WB, IP, IF and IHC(P). Bcr Antibody (G6) is available as the non-conjugated anti-Bcr antibody form, as well as multiple conjugated forms of anti-Bcr antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases. It is of interest that the GAP domain of Bcr maps outside of the region that remains on chromosome 22 (Philadelphia chromosome) in CML.