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Santa Cruz Biotechnology

ICAM-1 (15.2) Alexa Fluor® 405 | Santa Cruz Biotechnology

mouse monoclonal IgG1; ICAM-1/CD54 Antibody (15.2) is an IgG1 κ mouse monoclonal ICAM-1 antibody that detects ICAM-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. ICAM-1/CD54 Antibody (15.2) is available as the non-conjugated anti-ICAM-1 antibody form, as well as multiple conjugated forms of anti-ICAM-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play important, yet separate, roles in embryogenesis and development. The intracellular adhesion molecule-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the β2α1 and β2αM Integrins. ICAM-2 functions as a ligand for lymphocyte function-associated antigen-1 (LFA-1) and is involved in leukocyte adhesion. ICAM-3 is highly expressed on the surface of human eosinophils and, when bound to ligand, may inhibit eosinophil inflammatory responses and survival. ICAM-4, also known as LW glycoprotein, interacts with Integrins αLβ2, αMβ2, α4β1, the αV family and αIIbβ3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM-5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecule for leukocyte binding in the central nervous system.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.