mouse monoclonal IgG1; PEA3 Antibody (16) is an IgG1 κ mouse monoclonal PEA3 antibody that detects PEA3 p60 of mouse, rat and human origin by WB, IP and IF. PEA3 Antibody (16) is available as the non-conjugated anti-PEA3 antibody form, as well as multiple conjugated forms of anti-PEA3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Several members of the Ets gene family are known to encode sequence-specific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5′-GGAA-3′ element. For instance, PEA3 binds the motif 5′-AGGAAG-3′ (the PEA-3 motif), but does not bind to the sequence 5′-AGGAAC-3′, recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.