mouse monoclonal IgG1; CD5 Antibody (UCH-T2) is an IgG1 κ mouse monoclonal CD5 antibody (also designated CD5 antibody) that detects the CD5 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. CD5 Antibody (UCH-T2) is available as both the non-conjugated anti-CD5 antibody form, as well as multiple conjugated forms of anti-CD5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-z chain and with the Src family kinase Lck p56. In vitro studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection.