mouse monoclonal IgG2a; Syk Antibody (4D10) is an IgG2a κ mouse monoclonal Syk antibody (also designated spleen tyrosine kinase antibody or p72-Syk antibody) that detects the Syk protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. Syk Antibody (4D10) is available as both the non-conjugated anti-Syk antibody form, as well as multiple conjugated forms of anti-Syk antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Specifically, calcium ions travel through either a phosphoinositide 3-kinase (PI 3-kinase)-dependent pathway when Syk is not phosphorylated, or through a phospholipase C (PLC) γ-dependent pathway when human Syk is phohsphorylated on Tyr 348 and Tyr 352. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.