mouse monoclonal IgG2b; TFIID Antibody (TBP) is an IgG2b mouse monoclonal TFIID antibody (also designated TBP antibody, TF2D antibody, GTF2D1 antibody or TATA binding protein TBP antibody) that detects the TFIID protein of mouse, rat, human and Drosophila melanogaster origin by WB, IP and IF. TFIID Antibody (TBP) is available as both the non-conjugated anti-TFIID antibody form, as well as multiple conjugated forms of anti-TFIID antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. Binding of TFIID to the TATA element initiates assembly of the other factors into a pre-initiation complex. The TATA-binding subunit of TFIID (designated TFIIDt or TBP) from higher eukaryotes contains a highly conserved 180 amino acid C-terminal domain.