Companies / Santa Cruz Biotechnology / cyclin D2 (34B1-3) Alexa Fluor® 647
Santa Cruz Biotechnology

cyclin D2 (34B1-3) Alexa Fluor® 647 | Santa Cruz Biotechnology

rat monoclonal IgG2a; cyclin D2 Antibody (34B1-3) is an IgG2a rat monoclonal cyclin D2 antibody that detects cyclin D2 and, to a lesser extent, cyclin D1 of mouse, rat and human origin by WB, IP, IF and IHC(P). cyclin D2 Antibody (34B1-3) is available as the non-conjugated anti-cyclin D2 antibody form, as well as multiple conjugated forms of anti-cyclin D2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl-1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.

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Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.