mouse monoclonal IgG1; HPV16 E6/18 E6 Antibody (C1P5) is an IgG1 κ mouse monoclonal HPV16 E6/18 E6 antibody (also designated human papillomavirus type 16 transforming protein E6 antibody, HPV16 E6 antibody, human papillomavirus type 18 transforming protein E6 antibody, HPV18 E6 antibody, alpha papillomavirus 7 (HPV18) E6 protein antibody, alpha papillomavirus 9 (HPV16) E6 protein antibody, HpV16gp1 (E6) antibody, or HpV18gp1 (E8) antibody) that detects the HPV16 E6/18 E6 protein of HPV 16 and HPV 18 origin by WB, IP, IF and IHC(P). HPV16 E6/18 E6 Antibody (C1P5) is available as both the non-conjugated anti-HPV16 E6/18 E6 antibody form, as well as multiple conjugated forms of anti-HPV16 E6/18 E6 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.