mouse monoclonal IgG2b; β Tubulin Antibody (D-10) is an IgG2b κ mouse monoclonal beta Tubulin antibody that detects the beta Tubulin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. β Tubulin Antibody (D-10) is available as both the non-conjugated anti-beta Tubulin antibody form, as well as multiple conjugated forms of anti-beta Tubulin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Tubulin is a major cytoskeleton component that has five distinct forms, designated α, β, γ, δ and e Tubulin. α and β Tubulins form heterodimers which multimerize to form a microtubule filament. Multiple β Tubulin isoforms (β1, β2, β3, β4, β5, β6 and β8) have been characterized and are expressed in mammalian tissues. β1 and β4 are present throughout the cytosol, β2 is present in the nuclei and nucleoplasm, and β3 is a neuron-specific cytoskeletal protein. γ Tubulin forms the gammasome, which is required for nucleating microtubule filaments at the centrosome. Both δ Tubulin and e Tubulin are associated with the centrosome. δ Tubulin is a homolog of the Chlamydomonas δ Tubulin Uni3 and is found in association with the centrioles, whereas e Tubulin localizes to the pericentriolar material. e Tubulin exhibits a cell-cycle-specific pattern of localization, first associating with only the older of the centrosomes in a newly duplicated pair and later associating with both centrosomes.