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Santa Cruz Biotechnology

IRAK-1 (F-4) Alexa Fluor® 546 | Santa Cruz Biotechnology

mouse monoclonal IgG1; IRAK-1 Antibody (F-4) is an IgG1 κ mouse monoclonal IRAK-1 antibody (also designated IRAK1 antibody, or interleukin 1 receptor associated kinase 1 antibody) that detects the IRAK-1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. IRAK-1 Antibody (F-4) is available as both the non-conjugated anti-IRAK-1 antibody form, as well as multiple conjugated forms of anti-IRAK-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1a and IL-1b, and a specific receptor antagonist, IL-1Ra. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFkB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFkB.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.