mouse monoclonal IgG1; Clusterin-α Antibody (B-5) is an IgG1 κ mouse monoclonal Clusterin-alpha antibody (also designated CLU antibody, KUB1 antibody, APOJ antibody and Apolipoprotein J antibody) that detects the Clusterin-alpha protein of human origin by WB, IP, IF, IHC(P) and ELISA. Clusterin-α Antibody (B-5) is available as both the non-conjugated anti-Clusterin-alpha antibody form, as well as multiple conjugated forms of anti-Clusterin-alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (ApoJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, α and β, are associated through disulfide bonds. The β subunit (also called ApoJα) corresponds to residues 23-227. The α subunit (also called ApoJβ) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences β-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer's disease pathogenesis.