Santa Cruz Biotechnology

Epo (B-4) HRP | Santa Cruz Biotechnology

mouse monoclonal IgG2b; Erythropoietin/EPO Antibody (B-4) is an IgG2b κ mouse monoclonal Epo antibody that detects Epo of mouse, rat and human origin by WB, IP, IF and ELISA. Erythropoietin/EPO Antibody (B-4) is available as the non-conjugated anti-Epo antibody form, as well as multiple conjugated forms of anti-Epo antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Erythropoietin, or Epo, is the primary factor responsible for regulating erythropoiesis during steady-state conditions and in response to blood loss and hemorrhage in the adult organism. In addition, Epo has also been shown to play a role in primitive embryonic erythropoiesis. Epo is synthesized by the kidney and stimulates the proliferation and maturation of bone marrow erythroid precursor cells. Circulating Epo is a 165 amino acid glycoprotein. The Epo receptor, EpoR, is a glycoprotein expressed on megakaryocytes, erythroid progenitors and endothelial cells. Overexpression of Epo is associated with several pathophysiological conditions, such as polycythemias vera, which is caused by the Epo-independent growth of erythrocytic progenitors from abnormal stem cells. A deficiency in Epo expression has been associated with afflictions such as anemia of chronic disease (ACD), frequently found in rheumatoid arthritis (RA) patients.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.