mouse monoclonal IgG2b; Cdc20 Antibody (H-7) is an IgG2b κ mouse monoclonal Cdc20 antibody that detects Cdc20 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Cdc20 Antibody (H-7) is available as the non-conjugated anti-Cdc20 antibody form, as well as multiple conjugated forms of anti-Cdc20 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cyclins, regulatory subunits which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13suc 1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase termed p55 CDC exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The Cdc20 transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. Cdc20 shows kinase activity towards a-casein and myelin basic protein.