mouse monoclonal IgG2b; PAI-1 Antibody (C-9) is an IgG2b κ mouse monoclonal PAI-1 antibody (also designated SERPINE1 antibody, or serpin family E member 1 antibody) that detects the PAI-1 protein of human origin by WB, IP, IF, IHC(P) and ELISA. PAI-1 Antibody (C-9) is available as both the non-conjugated anti-PAI-1 antibody form, as well as multiple conjugated forms of anti-PAI-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the Trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.