Santa Cruz Biotechnology

WASP (D-1) | Santa Cruz Biotechnology

mouse monoclonal IgG1; WASP Antibody (D-1) is an IgG1 κ mouse monoclonal WASP antibody (also designated WASP antibody or Wiskott-Aldrich Syndrome Protein antibody) that detects WASP of human origin by WB, IP, IF, IHC(P), FCM and ELISA. WASP Antibody (D-1) is available as the non-conjugated anti-WASP antibody form, as well as multiple conjugated forms of anti-WASP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.