mouse monoclonal IgG1; CD74 Antibody (LN-2) is an IgG1 κ mouse monoclonal CD74 antibody (also designated HLA class II histocompatibility antigen gamma chain antibody) that detects the CD74 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. CD74 Antibody (LN-2) is available as both the non-conjugated anti-CD74 antibody form, as well as multiple conjugated forms of anti-CD74 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides. One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74. The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74.