mouse monoclonal IgA; JAK3 Antibody (B-12) is an IgA κ mouse monoclonal JAK3 antibody (also designated Tyrosine-protein kinase JAK-3 antibody, Janus kinase (JAK) family tyrosine kinase 3 antibody, or 120-130 kDa cytosolic tyrosine kinase JAK-3 antibody) that detects the JAK3 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. JAK3 Antibody (B-12) is available as both the non-conjugated anti-JAK3 antibody form, as well as multiple conjugated forms of anti-JAK3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.