mouse monoclonal IgG2a; Trk Antibody (B-3) is an IgG2a κ mouse monoclonal Trk antibody (also designated Pan Trk antibody, TRKA/B/C antibody or NTRK1/2/3 antibody ) that detects the Trk protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Trk Antibody (B-3) is available as both the non-conjugated anti-Trk antibody form, as well as multiple conjugated forms of anti-Trk antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for neurotrophin-3 (NT-3).