Companies / Santa Cruz Biotechnology / TAF II p130 (4A6) Alexa Fluor® 488
Santa Cruz Biotechnology

TAF II p130 (4A6) Alexa Fluor® 488 | Santa Cruz Biotechnology

mouse monoclonal IgG2a; TAF II p130 Antibody (4A6) is an IgG2a κ mouse monoclonal TAF II p130 antibody (also designated TAF II p130 antibody) that detects the TAF II p130 protein of human origin by WB, IP, IF and IHC(P). TAF II p130 Antibody (4A6) is available as both the non-conjugated anti-TAF II p130 antibody form, as well as multiple conjugated forms of anti-TAF II p130 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TFIID is a general transcription factor which initiates preinitiation complex assembly through direct interaction with the TATA promoter element. It is a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs). Although native TFIID can mediate both activator-independent (basal) and activator-dependent transcription in reconstituted systems, TBP can mediate only basal transcription. The largest subunit (TAF) of TFIID is a protein designated TAF II p250. Of interest, TAF II p250 has been cloned and shown to be identical to CCG1, a nuclear DNA-binding protein known to be important for cell cycle progression. This part of TAF II p250 may serve a specific function in activation of a subset of genes important for cell cycle progression. Human TAFII p130 is a coactivator for NFAT transcriptional activators that regulate the expression of cytokines.

Reviews


No reviews yet

ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.