mouse monoclonal IgG1; WT1 Antibody (F-6) is an IgG1 mouse monoclonal WT1 antibody that detects the WT1 protein of mouse, rat and human origin by WB, IP and IF. WT1 Antibody (F-6) is available as both the non-conjugated anti-WT1 antibody form, as well as multiple conjugated forms of anti-WT1 antibody, including agarose and multiple Alexa Fluor® conjugates. Wilms' tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms' tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino-terminus. The Wilms' tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs.