mouse monoclonal IgG2a; RARγ/Retinoic Acid Receptor γ Antibody (G-1) is an IgG2a κ mouse monoclonal RARγ antibody that detects RARγ1 and RARγ2 of mouse, rat and human origin by WB, IP and IF. RARγ/Retinoic Acid Receptor γ Antibody (G-1) is available as the non-conjugated anti-RARγ antibody form, as well as multiple conjugated forms of anti-RARγ antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Retinoids are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that modulate the effects of retinoids (RA) on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RA binds RARs, inducing a change in receptor configuration that allows DNA binding and increased gene transcription from specific genes to occur. RAR family members, which include RARα, RARβ and RARγ, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Retinoid receptor expression is tissue specific; the skin expresses RARγ and RXRα. The expression of RARγ and RXRβ was somewhat decreased in lung cancers. The human RARγ gene maps to chromosome 12q13.