mouse monoclonal IgG1; IFN-α/βRα Antibody (H-11) is an IgG1 κ mouse monoclonal IFN- alpha / beta R alpha antibody (also designated Interferon Alpha And Beta Receptor Subunit 1 antibody, Cytokine Receptor Family 2 Member 1 antibody, Interferon Alpha/Beta Receptor 1 antibody, Type I Interferon Receptor 1 antibody, IFN-Alpha/Beta Receptor 1 antibody, IFN-R-1 antibody, CRF2-1 antibody, IFNAR antibody, IFRC antibody, Interferon-Alpha/Beta Receptor Alpha Chain antibody, Alpha-Type Antiviral Protein antibody, Beta-Type Antiviral Protein antibody, Interferon-Beta Receptor 1 antibody, or Interferon Receptor 1 antibody) that detects the IFN- alpha / beta R alpha protein of mouse, rat and human origin by WB, IP and IF. IFN-α/βRα Antibody (H-11) is available as both the non-conjugated anti-IFN- alpha / beta R alpha antibody form, as well as multiple conjugated forms of anti-IFN- alpha / beta R alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The type I interferons (IFNs), α and β, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The α and β IFNs appear to compete with one another for binding to a common cell surface receptor while immune IFN (IFNγ) binds to a distinct receptor. The latter protein, IFN-αR, is only weakly responsive to type I interferons in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-α subtypes. Moreover, IFN-α/βR is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. The IFN-γ receptor complex consists of an alpha subunit (IFN-γRα) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).