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Santa Cruz Biotechnology

p-c-Jun (KM-1) Alexa Fluor® 647 | Santa Cruz Biotechnology

mouse monoclonal IgG1; p-c-Jun Antibody (KM-1) is an IgG1 κ mouse monoclonal p-c-Jun antibody that detects c-Jun p39 phosphorylated on Serine 63 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. p-c-Jun Antibody (KM-1) is available as the non-conjugated anti-p-c-Jun antibody form, as well as multiple conjugated forms of anti-p-c-Jun antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1 (3,4), originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is deactivated upon phosphorylation induced by the cAMP-dependent protein kinase A (PKA).

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.