APR 25, 2022 3:00 AM PDT

Exercise Reduces Proliferation of Colon Cancer Cells

WRITTEN BY: Katie Kokolus

Substantial evidence supports the association between exercise and reduced risk of colon cancer.  Physical activity also reduces mortality and recurrence in those diagnosed with colon cancer.  However, while it is generally accepted that exercise is beneficial, the exact biological mechanisms to explain this benefit remain unclear. 

Obtaining a clear and complete understanding of the biological links underlying the relationship between exercise and reduced colon cancer risk is imperative for developing the most effective treatment options for patients.  A manuscript recently published in Cancer Therapy and Prevention provides some new insight into the effect of exercise on colon cancer progression. 

The researchers recruited men at high risk for colon cancer to participate in the study.  Recruitment criteria required participants be at least 50 years of age and have a body mass index of at least 25 kg/m2.  Importantly, participants were required to be physically inactive for at least three months.  Physical inactivity was defined as not engaging in 30 minutes of moderate to vigorous-intensity physical activity three times a week. 

The study recruited 16 men to participate in the study.  The men participated in a moderate-intensity aerobic interval exercise on a stationary bicycle.  Each exercise session consisted of a 10 minute warm-up of light resistance pedaling followed by six five minute intervals achieving 60% heart rate reserve (the difference between resting and maximum heart rate).  Between each of the six intervals, the participants had two and half minutes of recovery where they performed light resistance pedaling.  All exercise occurred under the supervision of research staff.  Researchers monitored heart rate throughout the session and took blood pressure measurements during each recovery period to ensure safety and adjust intensity if needed.  Blood was drawn immediately before and after the exercise session.  The participants also provided blood samples before and after 60 minutes of quiet, seated rest. 

In study utilized a human colon cancer cell line known as LoVo.  The LoVo cell line was derived using cells obtained from a 56-year-old patient with metastatic colon cancer.   The researchers stimulated LoVo cells with serum collected from the study participants to test the effect on cell proliferation results.  Increases in cancer cell proliferation results in cancer growth and this indicates a poor prognostic factor. 

When stimulating LoVo cells with serum collected post-exercise, cancer cell proliferation was reduced by about 6% compared to LoVo cells stimulated with control serum.  In addition, the study demonstrated that cells cultured with post-exercise serum showed less sign of DNA damage, a condition that can accelerate cancer progression.  Exercise also promoted an increase in expression of the inflammatory cytokine interleukin-6 (IL-6).    

The study suggests that aerobic exercise can inhibit colon cancer cell proliferation.  Further, the data shows that the mechanism linking exercise to reduced colon cancer progression may occur, at least in part, by IL-6-driven regulation of DNA damage. 

 

Sources: Med Sci Sports Exerc, J Clin Oncol, Can Ther Prev

About the Author
PhD
PhD in Tumor Immunology. I am interested in developing novel strategies to improve the efficacy of immunotherapies used to extend cancer survivorship.
You May Also Like
JUN 01, 2022
Clinical & Molecular DX
Personalized Cancer Vaccine Showing Promise in Treating Melanoma and Ovarian Cancer
JUN 01, 2022
Personalized Cancer Vaccine Showing Promise in Treating Melanoma and Ovarian Cancer
Cancer vaccines have been around for decades, but a unique neoantigen vaccine called NeoVax is making researchers hopefu ...
JUL 03, 2022
Cell & Molecular Biology
Reversing the Spread of a Deadly Cancer
JUL 03, 2022
Reversing the Spread of a Deadly Cancer
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC); the survival rate at five years after d ...
JUL 21, 2022
Cancer
Can Microrobots Deliver Chemotherapy Directly to a Tumor?
JUL 21, 2022
Can Microrobots Deliver Chemotherapy Directly to a Tumor?
Microrobotics, also called microbotics, is a field of study focusing on miniature robotics capable of carrying tiny comp ...
AUG 29, 2022
Health & Medicine
US-Funded Research to be Open Access by 2026 Under New Federal Guidance
AUG 29, 2022
US-Funded Research to be Open Access by 2026 Under New Federal Guidance
If you have ever done research for school or work, or simply been curious about a scientific finding and wanted to read ...
SEP 15, 2022
Immunology
How a Cancer-Causing Virus Evades Human Immunity
SEP 15, 2022
How a Cancer-Causing Virus Evades Human Immunity
While our immune system is usually able to identify and destroy pathogenic invaders like bacteria and viruses, those mic ...
OCT 04, 2022
Cardiology
Brisk Walking Reduces Risk of Heart Disease, Cancer, and More
OCT 04, 2022
Brisk Walking Reduces Risk of Heart Disease, Cancer, and More
Getting your steps in at a brisker pace reduces the risk of cancer, heart disease, dementia, and premature death.
Loading Comments...