AUG 22, 2021 10:38 AM PDT

Time-Restricted Eating Can Benefit Different Ages and Sexes

WRITTEN BY: Carmen Leitch

Some research has indicated that by restricting eating in various ways, lifespan could be extended. Time-restricted eating (TRE) dietary regimens, for example, aim to limit food consumption to specific hours. Some studies have suggested that TRE may help with weight loss, but these findings have involved male mouse models. New research by scientists at the Salk Institute has indicated that the advantages of TRE depend on age and sex, but TRE can still deliver several health benefits to both sexes, young and old. This work, published in Cell Reports, has determined that TRE could help people with fatty liver disease, type 2 diabetes, liver cancer, and potentially some infectious diseases.

The incidence of liver cancer has been on the rise, and the disease may start with glucose intolerance, which can lead to non-alcoholic fatty liver disease. Glucose intolerance is also related to the development of pre-diabetes and diabetes, so finding ways to treat glucose intolerance could help prevent several disorders. TRE may be one of those ways.

“For many TRE clinical interventions, the primary outcome is weight loss, but we’ve found that TRE is good not only for metabolic disease but also for increased resilience against infectious diseases and insulin resistance,” said Satchidananda Panda, a professor in Salk’s Regulatory Biology Laboratory.

Instead of using only young, male mice in this research, the scientists gave groups of male and female mice of two different ages (about the equivalent of twenty- and forty-year-old people) a high-fat, high-sugar diet.

An analysis of the tissues and various health parameters of the mice indicated that TRE could help prevent fatty liver disease in the mice, who would normally get the disease from their diet. The mice were also better at regulating glucose levels when subjected to TRE. When the researchers put a mouse model of sepsis on a TRE regimen, they also found that survival rates improved in both male and female septic mice.

Image credit: Pxfuel

Interestingly, muscle mass was increased and muscle performance was improved in the male mice subjected to TRE, compared to those that were not. The researchers suggested that TRE might also be a way to help elderly people increase their muscle mass, which could reduce the chance of dangerous falls.

The researchers are planning on continuing to study TRE; they are interested in whether TRE can help muscle repair or regeneration, and how it may affect metabolism.

“These are very exciting questions for us, and we look forward to studying them in more detail,” added Panda.

Sources: Salk Institute, Cell Reports

About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
AUG 26, 2021
Cell & Molecular Biology
Viral Infection Can Have a Lasting Impact on Cells
AUG 26, 2021
Viral Infection Can Have a Lasting Impact on Cells
When a virus infects a cell, it usually takes over the cell's machinery to start churning out viral particles, which are ...
OCT 04, 2021
Cancer
Predicting Progression-Free Survival in a Melanoma Study
OCT 04, 2021
Predicting Progression-Free Survival in a Melanoma Study
IsoPlexis’ Single-Cell Proteomics Predict Progression-Free Survival in Melanoma Study While advancements in oncolo ...
SEP 22, 2021
Health & Medicine
Genetic Mutation Improving Protein Translation Found to Slow Aging
SEP 22, 2021
Genetic Mutation Improving Protein Translation Found to Slow Aging
A study from University College London found a genetic mutation in a gene encoding for more accurate translation of prot ...
SEP 24, 2021
Chemistry & Physics
Protecting the Mango Plant with Signal Interference
SEP 24, 2021
Protecting the Mango Plant with Signal Interference
Researchers made huge steps in mitigating the virulence of a mango plant toxin by exploiting the bacteria and signal pat ...
OCT 14, 2021
Cell & Molecular Biology
Cutting Edge Tools Change Our View of the Nuclear Pore Complex
OCT 14, 2021
Cutting Edge Tools Change Our View of the Nuclear Pore Complex
There are many intricate molecular machines that perform essential functions, and this work has called a method used to ...
OCT 15, 2021
Genetics & Genomics
Genes Seem to Significantly Impact the Results We Get From Exercise
OCT 15, 2021
Genes Seem to Significantly Impact the Results We Get From Exercise
Individual health is shaped by many different factors, including the sequences and expression levels of genes, the makeu ...
Loading Comments...