MAY 16, 2022 8:00 AM PDT

How To Ensure You Are Using High Quality Laboratory Consumables That Produce Consistent Results

SPONSORED BY: Labcon

There are many important considerations when choosing your laboratory consumables. How do you know that the plastic labware you choose will consistently work for your research? Here are 5 essential things to look for:  

1. Product Performance Certification

Quality that has been certified is a critical attribute for laboratory consumables. While plastic labware may look simple, the precise geometric requirements that make pipette tips accurate and centrifuge tubes able to withstand breakage must fall within very narrow parameters to prevent product (and experiment) failures. To ensure control over every aspect of product quality, biotech company Labcon designs, manufactures, tests, packages, sterilizes and stores all offered products at their facility in Petaluma, CA. Labcon offers pipette tips, filter tips, centrifuge tubes, deep well plates and other essential labware. Each product comes with certified measurements, guaranteed lab performance, and contamination testing.

2. Country of Manufacturing

Information about the product’s country of manufacturing can be found on product packaging and associated paperwork. Domestic manufacturing, packaging and sterilization in the United States must adhere to strict oversight rules that govern resin quality, contamination testing, product consistency, sterility validation and storage.  It is important to consider how multi-site or overseas production could affect your product’s performance and reliability, and ultimately your experiments. Labcon’s use of a single site domestic facility ensures supply resilience that doesn’t depending on overseas manufacturing. Check the country of origin for the lab products you use to ensure consistency and quality.

3. Validation of the Sterilization Process

Knowing that your laboratory consumables are sterilized with a validated process is critical to ensuring the product you receive is free from contamination without being damaged during the sterilization process. To ensure your products reach the required Sterility Assurance Level (SAL) of 10-6, you should ask your consumables provider for information on their bioburden monitoring. If this monitoring is not happening quarterly, as required for genuinely sterile labware, you cannot be confident that the product has received a true sterilizing dose during sterilization. Importantly, the FDA states items must come from a documented sterile validation process to be labeled as STERILE. Labcon provides guaranteed sterility using electron beam sterilization and quarterly audits of their sterilization benchmarks with continuous monitoring of bioburden. Electron beam sterilization also delivers a sterilizing dose far faster than gamma radiation technologies. This rapid dosing produces less oxidative damage to plastic products. The resulting sterile products are free of the damage and extreme color changes produced by other sterilization methods and can produce centrifuge tubes that spin faster. This is why Labcon’s SuperClear centrifuge tubes have an RCF rating higher than any other centrifuge tube available on the market. Tips free of the embrittlement induced by gamma sterilization also fit pipettes better and can deliver more accurate volumes. Additionally, the gentle sterilization afforded by the electron beam technique helps to ensure consistency between different cases of product, and low chemical extractables. 

4. Environmentally-Safe Sterilization Process 

Sterilization processes can be harmful to both the product and the environment, so be sure to confirm your labware manufacturer is using the most environmentally responsible method. Electron beam is the cleanest, safest, and most environmentally responsible process for sterilizing medical devices and labware.  Gamma radiation relies on radioactive isotopes and leaves behind persistent, dangerous radioactive waste that must be disposed of, while the “e-beam” technique uses an electron beam that is switched on and off without leaving behind waste products. Ethylene oxide, another sterilization method, produces dangerous byproducts and can remain in product packaging well after the lethal dose of gas has been administered. Labcon’s use of electron beam sterilization continues its commitment to the environment and contributed to Labcon’s industry-leading ACT environmental scores for lab consumables, while also providing products that have been validated for sterility. A reminder that products offered without quarterly auditing remain “pre-sterile” and unvalidated to the 10-6 SAL requirement. 

5. Laboratory Testing and Quality Control 

You should ensure that the manufacturer of your products doesn’t consider labware “pieces of plastic,” but instead understands that small deviations in lab products can lead to catastrophic differences in experimental outcomes. Labcon’s on-site laboratory and quality control facility ensures that all manufactured lots of products are certified free of biological contaminants and will perform in real world lab bench environments. Products are tested for contaminants including ATP, endotoxins (pyrogens), RNase and DNase, protease, and DNA. Continuous monitoring of pipette tip fit and function with Labcon’s large collection of in-house pipettes ensures that tips dispense accurately and are available for most pipettes found in labs worldwide. Rigorous centrifugation and performance testing confirms the ability of Labcon centrifuge tubes to perform in challenging experimental conditions, including high speed centrifugation and sample freezing, and Labcon tubes are engineered to prevent sample leaking even under demanding conditions. 

In Summation 

By focusing on the quality, sterility and origin of your lab consumables, you can ensure that you have removed an important obstacle to producing consistency and reproducibility in challenging experiments and assays.  

About the Sponsor
Labcon North America was founded in Marin County, California in 1959. Our original name was Ways and Means, Inc. The name given to the company then reflected the newness of the plastics industry. We were founded to literally find the Ways and Means" to make plastic products. We made several small toys, vials for salt tablets, contact lense cases, cassette tape cartridges, and cigarette filter holders. Now over 60 years later we have grown to supply more than 1000 products to labs all over the world. We make more than a billion products every year.
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