MAR 18, 2020 7:13 PM PDT

Drug Could Effectively Treat a Lethal Blood Cancer

WRITTEN BY: Nouran Amin

A pricey drug, called tyrosine kinase inhibitor (TKI), is used to continuously treat the blood cancer Chronic Myeloid Leukemia (CML).

The TKI treatment, if stopped, can cause the recurrence of CML. Even though most CML patients receive life-long TKI treatment—roughly 10 percent become resistant and progress to blast crisis (BC) CML. Once BC is reached, it is almost fatal and many factors that cause BC still remain unknown to clinicians.

"Our discovery is like finding the 'one ring that rules them all'. Since there are many cancer-causing genetic mutations that occur when chronic phase CML transforms to blast crisis, it has been very challenging to determine which ones are critical to BC, and therefore important to target. By discovering this 'one ring' and how to 'destroy' it with a novel drug combination, we open the door to treating this deadly cancer with the same combination of drugs regardless of the myriad mutations that exist in any particular patient. In addition, our study demonstrates the ability of scientists and clinicians to make exciting discoveries that can be translated to the improved health of patients all over the world, as well as Singaporeans," said Associate Professor Ong Sin Tiong from the Duke-NUS CSCB programme and corresponding author of this study.

Learn more about CML:

"As a haematologist treating patients with advanced blast crisis CML, it is disheartening when we run out of treatment options for them. And that is why we are very encouraged by the study findings and certainly hopeful that our patients may one day benefit from the efforts of our collaboration," Associate Professor Charles Chuah, Senior Consultant, Department of Haematology, SGH.

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JAN 09, 2020
Drug Discovery & Development
JAN 09, 2020
Can Cancer Drugs Treat Lung Damage?
Can therapeutics used in the treatment of cancer be a breakthrough for pulmonary disease? Specifically, chronic obstructive pulmonary disease (COPD)? &ldqu...
JAN 20, 2020
Cell & Molecular Biology
JAN 20, 2020
Using Modified Red Blood Cells As a Drug Delivery System
For a drug to be effective, it has to get to the right place to exert its impact....
JAN 20, 2020
Cancer
JAN 20, 2020
Did you know these non-cancer drugs can also fight cancer?
A study from MIT. Harvard and the Dana-Farber Cancer Institute has concluded that almost 50 existing non-oncological drugs have anti-cancer properties capa...
MAR 21, 2020
Technology
MAR 21, 2020
Modeling Mutations to Beat Drug Resistance
Mutations in bacteria or even cancer cells can make them resistant to drug treatments—that means they no longer respond to it and thus continue their...
MAR 28, 2020
Drug Discovery & Development
MAR 28, 2020
The Antibody Test to See if You've Already Had the Coronavirus
Knowing whether you’ve had the virus or not may not just reduce your need to panic- but also better help epidemiologists map out the spread of the vi...
APR 01, 2020
Cancer
APR 01, 2020
New immunotherapy for ovarian cancer
Research published recently in the Journal of Experimental Medicine suggests that targeting macrophages in a new kind of immunotherapy could provide hope f...
Loading Comments...