JUN 10, 2020 8:22 PM PDT

A Highly Targeted Cancer Therapeutic

WRITTEN BY: Nouran Amin

A study led by researchers at USC School of Pharmacy discusses a way to engineer drugs that highly target malignant tissues without affecting surrounding healthy tissues. These engineered compounds are known as ‘antibody-drug conjugates’ or ADCs that lead the way to better therapeutics for diverse types of cancer.

Learn more:

"Using our approach, homogenous ADCs could be made through a single-step reaction in less than two hours, much faster and more efficiently than conventional approaches," says the study's Principal Investigator, Yong (Tiger) Zhang, Assistant Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy.

As of now, only eight ADC drugs have been approved by the FDA after countless clinical trials evaluating their efficacy and safety in treating leukemia, breast cancer, lung cancer and so much more. The findings were published in Science Advances and describes how ADCs include an antibody that hunts for cancer and that antibody has a chemical linker that is “linking it” to a drug eventually uniting them and eradicating the cancer. This is precisely what makes ADC such an engineered targeted approach.

"Our technology features a designer 'linker' component exclusively recognized by a human enzyme that can rapidly catalyze the conjugation of drug molecules to the antibodies at a defined position," he says. "In addition to its fast rate and high efficiency, our ADC technology offers a new type of linker for connecting the drugs to antibodies. This designer linker ensures stable attachment of the drug and rapid release of the drugs into target cells, making the generated ADCs safer and more efficacious."

Source:  Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUN 10, 2020
Cannabis Sciences
Cannabis Temporarily Relieves PTSD Symptoms
JUN 10, 2020
Cannabis Temporarily Relieves PTSD Symptoms
PTSD (Post Traumatic Stress Disorder) is a mental disorder characterized by flashbacks, nightmares, and severe anxiety f ...
JUN 16, 2020
Microbiology
Dexamethasone Hailed as Effective COVID-19 Treatment
JUN 16, 2020
Dexamethasone Hailed as Effective COVID-19 Treatment
The pandemic virus SARS-CoV-2, which causes COVID-19, has killed more than 438,000 people worldwide since it emerged lat ...
JUN 23, 2020
Drug Discovery & Development
Psychedelic DMT to Enter Clinical Trials
JUN 23, 2020
Psychedelic DMT to Enter Clinical Trials
Neuro-pharmaceutical company, MindMed, has announced that it will begin a double-blind placebo-controlled Phase 1 clinic ...
JUN 26, 2020
Drug Discovery & Development
Bacterial Virus May Treat and Prevent COVID-19 Infections
JUN 26, 2020
Bacterial Virus May Treat and Prevent COVID-19 Infections
Researchers say that a type of virus known to infect bacteria could be used to treat and prevent COVID-19 bacterial infe ...
JUL 26, 2020
Drug Discovery & Development
Seaweed Extract Outperforms Remdesivir in Blocking COVID-19
JUL 26, 2020
Seaweed Extract Outperforms Remdesivir in Blocking COVID-19
An extract from seaweed has outperformed Remdesivir in ousting COVID-19 during cellular tests, according to new research ...
JUL 14, 2020
Drug Discovery & Development
Less Addictive Opioid
JUL 14, 2020
Less Addictive Opioid
Opioids continue to have a bad name, and for a good reason, the number of lives they took due to their abuse has led to ...
Loading Comments...