SEP 10, 2020 5:12 PM PDT

Improving Chemotherapeutic Delivery

WRITTEN BY: Nouran Amin

One particular form of stubborn cancer, known as hepatocellular carcinoma, has been challenging to treat and as a result it’s associated with a high mortality rate. Current treatment involves transarterial chemoembolization, an imprecise and invasive form of local drug delivery. Working to address these issues, scientists at Tulane University developed a combination therapeutic that involves vaporizing the tiny droplets of perfluorocarbon (organic substance composed of carbon and fluorine). The form of gas embolization was published in APL Bioengineering.

"By changing the treatment parameters in this paper, we were able to achieve tumor regression, and by combining our method with chemotherapy, we were able to reduce regrowth following treatment," author Joseph Bull said. "Gas embolization has never been used in patients. Demonstrating that it can induce tumor regression is really new. We're very excited about the work in this paper."

The method was tested in combination of doxorubicin (DOX) and tirapazamine, two common cancer drugs. The combination was so effective that it shrunk tumors on average to 2.9% of their original size.

Learn more about hepatocellular carcinoma:

 

 

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
AUG 22, 2020
Drug Discovery & Development
Could a Drug for Bipolar Disorder Treat COVID-19?
AUG 22, 2020
Could a Drug for Bipolar Disorder Treat COVID-19?
Researchers have found that a drug currently used to treat bipolar disorder and hearing loss may also treat COVID-19 tha ...
AUG 24, 2020
Cell & Molecular Biology
A Shield Surrounds the Flexible SARS-CoV-2 Spike Protein
AUG 24, 2020
A Shield Surrounds the Flexible SARS-CoV-2 Spike Protein
Researchers know that the viruses including SARS-CoV-2 have a Spike protein that allows them to bind to receptors on hos ...
SEP 11, 2020
Drug Discovery & Development
Single Injection Sends Type 2 Diabetes into Remission
SEP 11, 2020
Single Injection Sends Type 2 Diabetes into Remission
Type 2 diabetes affects around 10% of people in the US. Although there is no cure for it, there are some well-known meth ...
SEP 15, 2020
Drug Discovery & Development
Turmeric Better than Placebo for Osteoarthritis Pain
SEP 15, 2020
Turmeric Better than Placebo for Osteoarthritis Pain
Researchers from the University of Tasmania in Australia have found that an extract from turmeric is more effective than ...
SEP 20, 2020
Drug Discovery & Development
Cholesterol-Lowering Drugs Reduce The Severity of COVID-19
SEP 20, 2020
Cholesterol-Lowering Drugs Reduce The Severity of COVID-19
Almost a year into the beginnings of the COVID-19 pandemic and we still do not have a Food and Drug Administration (FDA) ...
OCT 01, 2020
Drug Discovery & Development
HPV Vaccine Protects Against Cervical Cancer, Large Study Finds
OCT 01, 2020
HPV Vaccine Protects Against Cervical Cancer, Large Study Finds
It has been known for some time that the HPV vaccine protects against human papillomavirus infection, genital warts, and ...
Loading Comments...