SEP 19, 2022 3:00 PM PDT

Labroots 2022 Microbiology Virtual Week Poster Winner: Dr. Emmanuel Ogbonna

Labroots’ virtual events are a fantastic way to network and learn about the work of other researchers in your field. These events feature participants from around the world who can showcase their research for free in a virtual poster format. At this year’s Microbiology Virtual Week (now available to view On-Demand), Labroots highlighted an exceptional study involving the fight against tuberculosis (TB). This distinctive work comes from Dr. Emmanuel Ogbonna, a Postdoctoral Research Fellow at Harvard Medical School, but the research itself was conducted when he was still a PhD student at the University of Delaware.

(To see the full poster in detail, check out the 2022 Microbiology Virtual Week On-Demand)

Ogbonna’s poster examined how the ATP-dependent protease ClpC1P1P2 is the target for new drug techniques, specifically against multi-drug resistant Mycobacterium tuberculosis (Mtb). The findings include new evidence that reinforces the presence of phosphoarginine-mediated proteolysis by the ATP-dependent protease ClpC1P1P2 in mycobacteria and other species of actinobacteria.

Ogbonna told Labroots that the most meaningful result of the project was the potential of N-methylhydantoinase to influence both ATPase and peptidase stimulatory pursuits of ClpC1. Ogbonna notes that the multi-pronged outcome strongly advocates that the modulation/regulation is built on configuration change.

“The goal of my research is to develop novel drugs against TB,” Ogbonna said. “So, a regulator like Nmh which almost completely shuts off an enzyme (ClpC1P1P2 protease) essential for the pathogen's viability presents an avenue for the development of synthetic mimics (e.g peptides) to target the pathogen.”

As a Postdoctoral Research Fellow at Harvard Medical School, Ogbonna continues his studies into TB progression, albeit from a tissue pathology vantage point using multiplex imaging techniques and single cell phenotyping.

The full manuscript for this project is currently in review but can be viewed now on bioRxiv. To follow Dr. Ogbonna’s research and career, and to connect with him, check out his LinkedIn page.

About the Author
MS in Geological Sciences
Laurence Tognetti is a six-year USAF Veteran who earned both a BSc and MSc from the School of Earth and Space Exploration at Arizona State University. Laurence is extremely passionate about outer space and science communication, and is the author of “Outer Solar System Moons: Your Personal 3D Journey”.
You May Also Like
SEP 02, 2022
Coronavirus
Omicron-Specific Booster Shots Will be Available Soon
SEP 02, 2022
Omicron-Specific Booster Shots Will be Available Soon
Soon, vaccine booster shots that are specific to the Omicron variant will be available in many countries. The new Omicro ...
OCT 12, 2022
Health & Medicine
Cavity-Causing Germs Can Form Superorganisms Able to Crawl on Teeth
OCT 12, 2022
Cavity-Causing Germs Can Form Superorganisms Able to Crawl on Teeth
Scientists have found that bacteria and fungi in the human mouth can join forces to form a superorganism that is stronge ...
NOV 23, 2022
Clinical & Molecular DX
Novel Human Cell Depletion Method Enables Rapid Pathogen Identification by Metagenomic Next-Generation Sequencing
NOV 23, 2022
Novel Human Cell Depletion Method Enables Rapid Pathogen Identification by Metagenomic Next-Generation Sequencing
Infection related severe pneumonia and sepsis are often life- threatening. Sepsis alone, kills approximately 11 million ...
NOV 24, 2022
Microbiology
The Germs in Hospitals are a Bigger Threat Than Those on Farms
NOV 24, 2022
The Germs in Hospitals are a Bigger Threat Than Those on Farms
Researchers sought to learn how dangerous drug-resistant Klebsiella, which can be found in many places, like farms, hosp ...
NOV 26, 2022
Coronavirus
Departing Chief Scientist of WHO Has Some Regrets
NOV 26, 2022
Departing Chief Scientist of WHO Has Some Regrets
Dr. Soumya Swaminathan acknowledged that not calling SARS-CoV-2 airborne "forcefully" earlier in the pandemic was a mist ...
DEC 03, 2022
Neuroscience
Eliminating Certain Gut Bacteria Causes Mice to Binge-Eat High-Sugar Foods
DEC 03, 2022
Eliminating Certain Gut Bacteria Causes Mice to Binge-Eat High-Sugar Foods
Suppressing certain gut bacteria leads mice to binge-eat foods high in sugar. The corresponding study was published ...
Loading Comments...