AUG 29, 2023 11:17 AM PDT

Breakthrough Study Reveals Promising Treatment for Chorea in Huntington's Disease

WRITTEN BY: Greta Anne

Huntington's disease is a genetic neurodegenerative disorder that affects both motor and cognitive function and gradually reduces the independence and quality of life of those affected. One of the hallmark symptoms of this condition is chorea - involuntary, jerky movements that can impair a person's ability to perform everyday tasks. While there has been a lack of effective treatments for chorea associated with Huntington's disease, a recent clinical study published in The Lancet: Neurology, named "KINECT-HD," has offered new hope. 

The KINECT-HD study was designed to evaluate the efficacy and safety of valbenazine, a medication specifically developed to target chorea in individuals with Huntington's disease. Chorea can lead to a host of physical, mental, and emotional challenges, making it a critical area for therapeutic intervention. The study design included a randomized, double-blind, placebo-controlled approach, ensuring that the results obtained were credible and reliable.

The primary objective of the study was to assess the change in chorea severity, measured through the Unified Huntington's Disease Rating Scale Total Maximal Chorea (UHDRS TMC) score. Individuals treated with valbenazine exhibited significant improvements in their UHDRS TMC score (chorea severity) compared to those receiving the placebo. This primary endpoint was a significant breakthrough as it provides hope that treating chorea is in the somewhat near future.

Additionally, the study also explored secondary endpoints that provided a comprehensive understanding of valbenazine's impact. The Clinical Global Impression of Change (CGI-C) and Patient Global Impression of Change (PGI-C) response status were evaluated, showing that patients treated with valbenazine experienced statistically significant improvements in response status compared to the placebo group. 

The results of the KINECT-HD study hold significant promise for individuals living with Huntington's disease and chorea. Chorea not only impacts physical mobility but also affects mental and emotional well-being. By providing relief from chorea symptoms, valbenazine has the potential to improve the overall quality of life for affected individuals. This study marks a crucial milestone in the journey to develop effective treatments for Huntington's disease and future studies are highly anticipated.


Sources: National Institute of Neurological Disorders and StrokeClinicalTrials.govThe Lancet Neurology

About the Author
Bachelor's (BA/BS/Other)
Greta is currently a writer at Labroots and a 3rd year Doctor of Pharmacy student, with a Bachelor of Science degree in Physiology and Neurobiology. Innovation is her passion, especially when it comes to pharma, entrepreneurship, science, and art. She is hoping to pursue a career in pharma while also fostering her creative initiatives.
You May Also Like
Loading Comments...
  • See More