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APR 7, 2021

Bioprocessing 2021

LabRoots is pleased to announce the 3rd Annual Bioprocessing Virtual Event! Join us for this free, one-day event on April 7, 2021 as we discuss upstream and downstream processing, analytical development and quality, formulation and stability, cell and gene therapy production, and manufacturing.

This year's event includes the following topics:

Upstream Processing

  • Cell Culture Optimization and Cell Line Development
  • Bioproduction: Scale, Bioreactors and Disposables

Downstream Processing

  • Continuous Processing
  • Advances in Purification and Recovery
  • Detection and Characterization of Impurities in Biologics

Analytical & Quality

  • Analytical Development
  • Characterization of Novel Biotherapeutics
  • Process Characterization & Control
  • Rapid Methods to Access Quality and Stability of Biologics

Cell and Gene Therapies

  • Cell Therapy Manufacturing/Analytics
  • Gene Therapy Manufacturing/Analytics
  • Regulations and Standards

Manufacturing

  • Vaccine Manufacturing
  • Digital Biomanufacturing

Our virtual conference allows you to participate in a global setting with no travel or cost to you. The event will remain open for 2 years from the date of the live event, and the webinars will be available for unlimited on-demand viewing.  This virtual conference also offers increased reach for the global microbiology community with a high degree of interaction through live-streaming video and chat sessions.

Like the 2020 conference, this event will be produced on our robust platform, allowing you to watch, learn and connect seamlessly across all desktop or mobile devices. Equipped with gamification and point system, you can now move around the entire event, earning points for a chance to win one of LabRoots' most popular T-shirts.


Call for Posters — Virtual poster sessions offer the opportunity to present data to a global audience via a PDF poster and video summary, and discuss results with interested colleagues through email. Plan now to have your poster included in the 2021 BioProcessing Virtual Event. Submission is free. Submit your abstract here.

Continuing Education
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this event, you can earn 1 Continuing Education credit per presentation for a maximum of 35 credits.

Use #LRbioprocessing to follow the conversation!


Speakers
  • Associate Professor in Fermentation and Cell Culture, Department of Biochemical Engineering University College London
  • Post-doctoral Fellow Boston Children's Hospital - Harvard; Affiliate researcher - MIT
  • CEO Novasign GmbH, Project Lead BOKU - Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna
  • Researcher at the Massachusetts Institute of Technology (MIT)
  • Scientist, Technical Operations, Sana Biotechnology
  • Research scholar, National Forensic Sciences University (NFSU)
  • Product Support and Development Manager at Astrea Bioseparations Ltd.
  • Professor, BioMedical Systems Engineering Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
  • Associate Director, Culture Development Seattle Cell Culture Development, Lundbeck Seattle BioPharmaceuticals, Inc
  • PhD Candidate, Bioinformatics & Systems Biology, University of California, San Diego
  • Technical Support Scientist (Mirus Bio)
  • Head of the Computational Bioprocess Engineering Group at the Institute for Process and Particle Engineering, Graz University of Technology
  • Professor, Chemical and Biomolecular Engineering, Ohio State University

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Agenda
  • Optimizing Transfection to Generate High-Titer AAV and Lentiviral Vectors
    APR 07, 2021 12:00 PM PDT
    Sandy Tseng, PhD
    Technical Support Scientist (Mirus Bio)
    Sponsored By: Mirus
  • An Evolution in Disposable Solutions
    APR 07, 2021 10:30 AM PDT
    Buzz Lobbezoo
    Product Support and Development Manager at Astrea Bioseparations Ltd.
    Sponsored By: Astrea Bioseparations
  • Keynote Presentation: Doing more with less - Maximizing Phase Appropriate DOE Strategies
    APR 07, 2021 9:00 AM PDT
    Patricia McNeill
    Associate Director, Culture Development Seattle Cell Culture Development, Lundbeck Seattle BioPharmaceuticals, Inc
    Sponsored By: Roche Diagnostics
  • Keynote Presentation: A Convenient Self-Cleaving Affinity Tag for Research and Manufacturing Applications
    APR 07, 2021 7:30 AM PDT
    David Wood
    Professor, Chemical and Biomolecular Engineering, Ohio State University
  • A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells
    Isaac Shamie
    PhD Candidate, Bioinformatics & Systems Biology, University of California, San Diego
  • A Next Generation Simulation Tool for the Characterization and Optimization of gassed and/or stirred Bioreactors
    Christian Witz, Ph.D.
    Head of the Computational Bioprocess Engineering Group at the Institute for Process and Particle Engineering, Graz University of Technology
  • Anti-fibrotic materials for immunoprotected cell-based therapies
    Matthew Bochenek, Ph.D.
    Post-doctoral Fellow Boston Children's Hospital - Harvard; Affiliate researcher - MIT
  • Characterisation and Scale Translation of a parallel Microbioreactor System for Cell Culture Process Development
    Frank Baganz, PhD
    Associate Professor in Fermentation and Cell Culture, Department of Biochemical Engineering University College London
  • Development of Potency Assays for Cell and Gene Therapy
    Nagarjun Kasaraneni, PhD
    Scientist, Technical Operations, Sana Biotechnology
  • From experiments, data, hybrid models, and digital twins. Several up- and downstream success stories highlighting the benefits of using advanced process modeling
    Dr. Mark Dürkop
    CEO Novasign GmbH, Project Lead BOKU - Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna
  • Model-Based Design of Mammalian Cell Culture Media: Demonstration for GS-NS0 Cell Line
    Sakis Mantalaris, PhD, FAIMBE
    Professor, BioMedical Systems Engineering Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
  • Model-based Control for Continuous Viral Inactivation of Biopharmaceuticals
    Moo Sun Hong, MS
    Researcher at the Massachusetts Institute of Technology (MIT)
  • Niosomes as a bilayer nanocarrier for combinative drug delivery
    Pratik Kulkarni, PhD
    Research scholar, National Forensic Sciences University (NFSU)
  • Manufacturing
  • A Next Generation Simulation Tool for the Characterization and Optimization of gassed and/or stirred Bioreactors
    Christian Witz, Ph.D.
    Head of the Computational Bioprocess Engineering Group at the Institute for Process and Particle Engineering, Graz University of Technology
  • From experiments, data, hybrid models, and digital twins. Several up- and downstream success stories highlighting the benefits of using advanced process modeling
    Dr. Mark Dürkop
    CEO Novasign GmbH, Project Lead BOKU - Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna
  • Downstream Processing
  • Model-based Control for Continuous Viral Inactivation of Biopharmaceuticals
    Moo Sun Hong, MS
    Researcher at the Massachusetts Institute of Technology (MIT)
  • Keynote Presentation: A Convenient Self-Cleaving Affinity Tag for Research and Manufacturing Applications
    APR 07, 2021 7:30 AM PDT
    David Wood
    Professor, Chemical and Biomolecular Engineering, Ohio State University
  • Upstream Processing
  • A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells
    Isaac Shamie
    PhD Candidate, Bioinformatics & Systems Biology, University of California, San Diego
  • Characterisation and Scale Translation of a parallel Microbioreactor System for Cell Culture Process Development
    Frank Baganz, PhD
    Associate Professor in Fermentation and Cell Culture, Department of Biochemical Engineering University College London
  • Model-Based Design of Mammalian Cell Culture Media: Demonstration for GS-NS0 Cell Line
    Sakis Mantalaris, PhD, FAIMBE
    Professor, BioMedical Systems Engineering Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
  • Keynote Presentation: Doing more with less - Maximizing Phase Appropriate DOE Strategies
    APR 07, 2021 9:00 AM PDT
    Patricia McNeill
    Associate Director, Culture Development Seattle Cell Culture Development, Lundbeck Seattle BioPharmaceuticals, Inc
    Sponsored By: Roche Diagnostics
  • Analytical and Quality
  • Niosomes as a bilayer nanocarrier for combinative drug delivery
    Pratik Kulkarni, PhD
    Research scholar, National Forensic Sciences University (NFSU)
  • Cell and Gene Therapies
  • Development of Potency Assays for Cell and Gene Therapy
    Nagarjun Kasaraneni, PhD
    Scientist, Technical Operations, Sana Biotechnology
  • Anti-fibrotic materials for immunoprotected cell-based therapies
    Matthew Bochenek, Ph.D.
    Post-doctoral Fellow Boston Children's Hospital - Harvard; Affiliate researcher - MIT
Speakers

  • Frank Baganz, PhD
    Associate Professor in Fermentation and Cell Culture, Department of Biochemical Engineering University College London
    Biography

      After completion of a first degree in Chemical Engineering/Biotechnology (FHO Emden, Germany) he carried out a PhD in Applied Molecular Biology at UMIST (Manchester, UK). Following a short postdoctoral period in the Department of Biochemical Engineering at UCL he became a Lecturer and currently holds a position as Associate Professor. He has an established track record in modelling, engineering and scale-up/down of fermentation and cell culture processes. In recognition for his contributions to the development of miniature bioreactor technologies he received the 2010 Pharmaceuticals Division Plenary Award of the AIChE. He has published over 80 papers and co-authored 4 book chapters.

    • Matthew Bochenek, Ph.D.
      Post-doctoral Fellow Boston Children's Hospital - Harvard; Affiliate researcher - MIT
      Biography

        Matt Bochenek received his BS in Industrial and Enterprise Systems Engineering from the University of Illinois Urbana/Champaign. His interest in biological systems made him alter his focus, and he pursued a Ph.D. in Bioengineering at the University of Illinois at Chicago (UIC).  Here, he worked with Dr. Jose Oberholzer in a Phase III clinical trial for intraportal islet transplantation. This entails isolating insulin producing islet cells from human donor pancreata and transplanting them intraportally into Type I diabetic patients in order to restore glycemic control. Currently, he works as a senior post-doc in Dr. Dan Anderson and Dr. Bob Langer labs at MIT. and works for cell and. Matt’s work primarily focuses on the development of immunomodulatory biomaterials, specifically for the immuno-protection of islet cells and other cell-based therapies, as well for cancer therapies. Recently, he published in Nature BME to show that anti-fibrotic alginate modified materials can protect islet cells in non-human primates for up to 4 months without the need for immunosuppression.

      • Dr. Mark Dürkop
        CEO Novasign GmbH, Project Lead BOKU - Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna
        Biography
          With more than 10 years of experience, Mark is a passionate expert in the field of biopharmaceutical process development. He worked together with several Top25 Pharma companies in different projects targeting their needs in process development and understanding. Together with his team, he is developing a hybrid modeling software for both up and downstream processes. This software utilizes AI applied to process data and first principle models (hybrid models) to quickly predict critical quality attributes (CQAs) from critical process parameters (CPPs). Hereby, bioprocess development and characterization are accelerated significantly while simultaneously a better process understanding is gathered. From this research project, the company Novasign was founded in 2019 offering this unique software solution.
        • Moo Sun Hong, MS
          Researcher at the Massachusetts Institute of Technology (MIT)
          Biography
            Moo Sun Hong is a researcher at the Massachusetts Institute of Technology (MIT) in the group of Prof. Richard D. Braatz. Moo Sun received a B.S. in Chemical and Biological Engineering from Seoul National University and was the top graduate in its College of Engineering. He received an M.S. in Chemical Engineering Practice from MIT and the Jefferson W. Tester Prize for enthusiasm and leadership in the Practice School. He has constructed mathematical models for multiple bioreactor configurations and does research in the model-based design and control of continuous protein crystallization and viral inactivation.
          • Nagarjun Kasaraneni, PhD
            Scientist, Technical Operations, Sana Biotechnology
            Biography
              Nagarjun is a Scientist in Technical Operations at Sana Biotechnology (Cambridge, MA). He completed his PhD in Medical Sciences at Texas A&M University (Texas), where he worked on development of a universal lentiviral vector platform for different gene therapy applications. After his graduate school, he joined Lonza (Houston), as a research intern and worked on developing cell lines for high titer productivity of different viral vectors. Nagarjun currently works on analytical method development to develop fit for purpose genomic assays to characterize viral vectors across Sana gene therapy platforms.
            • Pratik Kulkarni, PhD
              Research scholar, National Forensic Sciences University (NFSU)
              Biography

                Mr. Pratik P. Kulkarni is a PhD. Research scholar (awaiting final defense) at the National Forensic Sciences University (NFSU). He received his bachelors in pharmacy from K.B Inst. Of Pharma. Edu. and Research, and a master’s degree in nano drug delivery systems from NFSU, Gandhinagar, India. His research interests include development of drug loaded nanocarriers for combinative drug delivery applications. Till now he has published 9 scientific papers in journals of International repute. His work on Breast cancer nanoformulation was awarded a place in the virtual issue titled “Most original and Most significant scientific contribution” in 2018 (Elsevier).

              • Buzz Lobbezoo
                Product Support and Development Manager at Astrea Bioseparations Ltd.
                Biography
                  As the Product Support & Development (PSD) Manager for Astrea Bioseparations Ltd, Buzz leads a small dedicated team providing full technical support and information for Astrea's products. Buzz joined Astrea in 2004 as a Research Scientist in the downstream purification team. In 2011 he became the Applications & Downstream Processing Specialist, and in 2016 was appointed the new role of PSD Manager. Buzz obtained his Biochemistry degree from University of Kent, then spent over 14 years in both the Research (University of Cambridge) and Biotech/Biopharmaceutical sectors (Adprotech, Metris and Celltech (now UCB)) before joining Astrea. He has significant product profiling and processing experience having worked on small-scale purification applications to large-scale manufacturing processes.
                • Sakis Mantalaris, PhD, FAIMBE
                  Professor, BioMedical Systems Engineering Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
                  Biography

                    Sakis Mantalaris is Professor in the W.H. Coulter Department of Biomedical Engineering at Georgia Tech & Emory. Prior, he was Professor of BioSystems Engineering in the Department of Chemical Engineering at Imperial College London. He received his PhD (2000) in Chemical Engineering from the University of Rochester. His expertise is in modelling of biological systems and bioprocesses with a focus on mammalian cell culture systems, stem cell bioprocessing, and tissue engineering. He has published over 170 original manuscripts, co-edited one book, and holds several patents with several more pending. He has received several awards including the Junior Moulton Award for best paper by the Institute of Chemical Engineers (IChemE) in 2004. In 2012, he was elected Fellow of the American Institute for Medical & Biological Engineering and in 2013 he was awarded a European Research Council (ERC) Advanced Award. In 2015, he was awarded the Donald Medal by the Institution of Chemical Engineers (IChemE) for his contributions to biochemical engineering.

                  • Patricia McNeill
                    Associate Director, Culture Development Seattle Cell Culture Development, Lundbeck Seattle BioPharmaceuticals, Inc
                    Biography

                      Patricia McNeill joined Lundbeck Seattle BioPharmaceuticals Inc. in October 2019  as part of the acquisition of Alder Biopharmaceuticals. As Associate Director of Cell Culture Development, she has overseen the successful upstream process development for early to late stage cell culture and fermentation processes producing therapeutic monoclonal antibodies. She was hired as the 10th employee at Alder and has since held progressive leadership roles including the build-out and expansion of the research development lab for yeast fermentation. As Alder grew and new production platforms were needed, Patricia was tasked in establishing a CHO cell culture platform from the ground up. Prior to Alder, Patricia worked at Corixa Corporation where she was responsible for production of E. coli antigens used in cancer vaccine therapies. Her passion is using Design of Experiment (DOE) studies to decrease Cost of Goods (COGs), increase process efficiency, and robustness, and speed up development timelines.

                    • Isaac Shamie
                      PhD Candidate, Bioinformatics & Systems Biology, University of California, San Diego
                      Biography

                        I am a 5th year PhD candidate in the Bioinformatics & Systems Biology program at UC San Diego with Dr. Nathan Lewis as my advisor. I received a B.S in Biology with a minor in computational neuroscience at Carnegie Mellon University, working on mu-opioid receptor recycling in Dr. Manoj Puthenveedu's lab. I then worked in Dr. Eric Halgren's lab, using ECog data to understand spatiotemporal patterns in sleep and memory. In the Lewis lab, my dissertation examines different points in the lifecycle of biopharmaceuticals, from production to application, using next-generation sequencing technology. My first project-the topic of my talk today- improves the resolution of the transcription start sites (TSSs) in the Chinese Hamster using comprehensive multi-omics across various tissues. This elucidated regulatory regions such as the TATA box and initiator element, enabled CRISPR activation for the Mgat3 gene, and provided a valuable resource for the CHO community. My second focus is on the application of a novel immuno-therapeutic to the clonal makeup of the hematopoietic CD34+ stem and progenitor cell population. Using a recently published single-cell mitochondrial ATAC-seq methodology for lineage tracing, we tracked clonal population expansions and regressions. I am very interested in genetic engineering in combination with sequencing and modeling techniques, and hope to incorporate these techniques to developing and understanding novel therapeutics.

                      • Sandy Tseng, PhD
                        Technical Support Scientist (Mirus Bio)
                        Biography

                          Sandy joined the technical support team at Mirus Bio in 2019 and is responsible for working with scientists on troubleshooting and optimization of their gene delivery experiments and workflows. Before joining Mirus Bio, Sandy completed her doctoral thesis on the topic of regulation of eukaryotic gene expression at the University of Wisconsin-Madison.

                        • Christian Witz, Ph.D.
                          Head of the Computational Bioprocess Engineering Group at the Institute for Process and Particle Engineering, Graz University of Technology
                          Biography

                            Christian Witz has studied chemical process engineering. In his Ph.D. Witz created a novel simulation program for aerated and stirred bioreactors. He was recently named as a fellow in the Spin-Off Fellowship program of the Austrian Research Promotion Agency.

                          • David Wood
                            Professor, Chemical and Biomolecular Engineering, Ohio State University
                            Biography

                              David Wood is a Professor of Chemical and Biomolecular Engineering at The Ohio State University.  He received his undergraduate degree from Caltech in 1990 with a double major in Chemical Engineering and Molecular Biology, and then worked on Neupogen® manufacturing at Amgen and downstream process development at Bristol Myers Squibb.  Since receiving his PhD from Rensselaer Polytechnic Institute over 20 years ago, professor Wood has developed groundbreaking new technologies in downstream bioprocessing with a focus on self-cleaving affinity tag methods.  His work has led to several issued patents in this area, and he is now a co-founder of Protein Capture Science, a startup company commercializing his self-cleaving affinity tag technology.

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                            C.E. Credits

                            The speakers below have been approved for Continuing Education Credits. To redeem your credits, locate the presentation you watched and click on the CE buttons for further direction. For more general information regarding continuing education, the processes to receive credits, and the accreditation bodies, Click here


                            Committee

                            To download the Program Committee brochure here.


                            • Nagarjun Kasaraneni, PhD

                              Nagarjun is a Scientist in Technical Operations at Sana Biotechnology (Cambridge, MA). He completed his PhD in Medical Sciences at Texas A&M University (Texas), where he worked on development of a universal lentiviral vector platform for different gene therapy applications. After ...

                              See more See less
                            • Dr. Mark Dürkop

                              With more than 10 years of experience, Mark is a passionate expert in the field of biopharmaceutical process development. He worked together with several Top25 Pharma companies in different projects targeting their needs in process development and understanding. Together with his ...

                              See more See less
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                            Posters

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                            Virtual poster sessions offer the opportunity to present data to a global audience via a PDF poster and video summary, and discuss results with interested colleagues through email. Posters should be submitted as a PowerPoint file. Presentations should incorporate illustrative materials such as tables, graphs, photographs, and large-print text. This content is not peer-reviewed. Submission is free.

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                            If accepted, you will also have the opportunity to record a 3-5 minute summary video for each poster. Labroots will work with each individual to create these videos. Video links and email contact information will be included on each poster displayed.

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