Staff Scientist, Bioinformatics, Thermo Fisher Scientific
BIOGRAPHY
SEP 12, 2018 8:00 AM PDT
Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
Speaker
Event Date & Time
DATE: September 12, 2018
TIME: 08:00am PDT, 11:00am EDT
Abstract
Immuno-Oncology Webinar Series (#3 of 3)
In the final presentation of this webinar series, we will continue our discussions of recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires to precision immunotherapy. Last month, Dr. Looney highlighted novel applications of long-amplicon TCRB sequencing. This month we introduce a newly launched short-amplicon TCRB sequencing assay designed to interrogate the TCRB CDR3 region from fresh or formalin-fixed paraffin-embedded (FFPE) samples. Dr. Looney will present data suggesting that short-amplicon TCRB repertoire sequencing of FFPE samples may be used to characterize T cell responses to tumor antigens through the assessment of T cell expansion, diversity and receptor convergence. Additionally, short-read sequencing of the peripheral blood may enable detection of low frequency malignant T cell clones for future minimal residual disease (MRD) monitoring applications.
Learning Objectives:
- Understand new applications of T cell receptor sequencing to immunotherapy translational research.
- Describe the advantages of short-amplicon TCRB sequencing via Ion Torrent for characterization of the tumor microenvironment
Register for our 3 Part Series here:
- #3 - Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
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Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
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