Affinity Proteomics and LC-MS synergize Biomarker Discovery

Grab your cup of coffee and join us for the next Multiomics Coffee Break with a presentation from Discovery Life Sciences, an Olink Certified Service Provider.

With Olink Certified Service Providers you can confidently outsource your projects to drive acceleration of your research with top-tier data quality, and seamless multiomics integration—from project planning to data delivery.

Affinity Proteomics and LC-MS synergize Biomarker Discovery, Characterization and Validation

Blood is an ideal, minimally invasive sample for biomarker discovery, but its complexity might make untargeted, deep proteomics challenging. This work compares plasma proteomics approaches using both Olink® Explore/Explore HT and LC-MS on the same samples. We analysed small cohorts of biofluids (urine, plasma, CSF, and dried blood spots) across both platforms, performing pathway analysis to highlight the complementarity of each data set. In a cohort of 40 COVID-19 patients, Olink Explore HT enabled precise measurement of cytokine storm markers, which are challenging for LC-MS, demonstrating the added depth provided by combining both technologies.

Join this webinar to learn:

• The power of a combined approach to effectively increase proteome coverage and facilitate biomarker discovery, characterization and validation.
• The complementarity of the two technologies: PEA has exceptional specificity and high sensitivity for low-abundance proteins with uncompromised throughput in all sample types, while LC-MS can achieve unbiased protein coverage and detection for isoforms and post-translational modifications for high-abundance proteins.

Register now and be a part of the multiomics revolution!

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