Animal Models for Tuberculosis Research

Speaker

Abstract

Tuberculosis (TB) is the No.1 cause of death due to a single infectious agent in the world today. According to the global report from World Health Organization, one third of world population is currently infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. Approximately 90% of those infected have latent TB and therefore are not infectious and have no TB symptoms; however, the remaining ~10% will develop active tuberculosis at some time during their lifetime, resulting in an estimated 10 million new TB cases and ~2 million deaths worldwide annually. While the successful implementation of DOTS (Directly Observed Treatment, Short-course) strategy has significantly decreased the global TB spread in the past two decades, the development of multidrug-resistant (MDR) and extremely drug-resistant (XDR) TB is now becoming a serious concern in high burden populations. To accelerate the global control of TB and limit the spread of drug-resistant TB, more effective anti-TB vaccines and drug regimens are needed. Additionally, it’s clear that we need a better understanding of the interaction between the M. tuberculosis and its host at the cellular and organism level. To address these questions, suitable experimental animal models of TB are required that mimic the course of human TB as well as reproduce the human body responses to TB vaccines and drug regimens. In this Webinare, we will highlight the different animal models in TB medical research, and discuss the issues around the appropriate choice of animal model in understanding host-pathogen interaction mechanisms during an M. tuberculsis infection, and evaluation of anti-TB vaccines and drugs. 


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
APR 20, 2021 11:00 AM PDT
C.E. CREDITS
APR 20, 2021 11:00 AM PDT
Date: April 20, 2021 Time: 11:00am (PST), 2:00pm (EST) Identification and confirmation of microbial isolates is crucial in the analysis workflow, providing decision-makers the information...
APR 19, 2021 8:00 AM PDT
C.E. CREDITS
APR 19, 2021 8:00 AM PDT
Date: Apri 19, 2021 Time: 8:00am PDT, 5:00pm CEST Since the inception of modern biological research, BioSafety has evolved into a critical consideration in Good Laboratory Practices (GLP). Wi...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
Loading Comments...
Show Resources