Investigating the Spatial Organization of the Immune Response in Tumors: Insights from the STAMP Model

Understanding the spatial organization of the immune response within tumors is crucial for developing effective cancer immunotherapies. In this seminar, we delve into the interactions between the tumor microenvironment and immune cells, focusing on how these interactions influence tumor progression and rejection. We introduce the Skin Tumor Array by Microporation (STAMP) model as a novel preclinical tool for studying tumor immunotypes and dynamics in real time. Through a series of experiments, we explore the cellular and molecular determinants of different immunotypes and demonstrate their dynamic nature over time. By studying the complexities of the tumor-immune microenvironment, our research aims to contribute to the development of more effective cancer treatments and improve patient outcomes.

Learning Objectives: 

1. Explain the significance of the Cancer Immunity Cycle, outlining its 6 key steps and how they contribute to the body's ability to recognize and eliminate tumors.

2. Identify the three T cell immunotypes and understand their relation to tumor regression/progression.

3. Describe one of the key cellular determinants of different immunotypes and their roles in shaping tumor fate.