FEB 15, 2024 8:00 AM PST

Breathe Easy with Better Models: Research for Activating Macrophages and Dendritic Cells with Nanomedicine in Lung Carcinoma

Sponsored by: Curiox

Event Date & Time
Date: February 15, 2024
Time: 8:00 AM (PST), 11:00 AM (EST), 5:00 PM (CET)
Macrophages can mediate phagocytosis of cancer cells and cytotoxic tumor killing, and engage in effective bidirectional interactions with components of the innate and adaptive immune system. Given the continuous recruitment of myelomonocytic cells into tumor tissues, macrophages are candidates for cell therapy with the development of chimeric antigen receptor effector cells.
For the tumor acidic environment (especially, in lung carcinomas), the goal is to describe the unique strategies involving nanomedicine-based co-delivery of a calcium channel inhibitor and CD47 inhibitor. The findings show that inhibitors TTA-Q9 and RRX-001 disrupt cancer cells' calcium uptake, leading to stress and calreticulin surface expression. This, in turn, activates macrophages and dendritic cells, enhancing T cell-driven antitumor activity.
This webinar will cover high-dimensional biology techniques and protocols that demonstrate cell killing capabilities of Tumor Associated Macrophages.
Learning Objectives
  • Utilize flow cytometric analysis for maturation of Bone Marrow Dendritic Cells and proliferation of CD8+ T cells
  • Describe polarization, killing effect, and swallowing function analysis of Alveolar macrophages
  • Discuss strategies to improve resolution when developing cellular functional assays using next generation tools, including Curiox Laminar WashTM technology.


Webinars will be available for unlimited on-demand viewing after live event.

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