Date: December 8, 2021
Time: 11:00am (PST), 2:00pm (EST)
Breast cancer is the most common type of cancer and the leading cause of cancer deaths for women. Despite considerable ongoing research efforts focused on increasing our understanding breast cancer tumorigenesis and progression, the factors that regulate human breast cancer development at the cellular and molecular level remain poorly understood. And there is a growing need for immune-competent human breast ex vivo models that recapitulate the native breast tissue microenvironment to help elucidate the underlying mechanisms of breast cancer risk factors. In this webinar, Dr. Xiaojiang Cui of Cedars-Sinai Medical Center will provide an overview of the most recent advances in 3D organoid models derived from induced pluripotent stem cells (iPSCs) and patient-specific breast tissue. He’ll discuss how his lab:
- Develops novel human breast tissue mimetic organoid model systems derived from fresh human breast tissue specimens from reduction mammaplasty reduction and prophylactic surgeries
- Studies cellular marker expression using a combination of imaging analysis techniques, including immunohistochemistry, immunofluorescence, and highly-multiplexed CODEX® spatial technology
- Plans to build on this foundational model system to faithfully recapitulate the physiology of human breast tissue in culture – and pave the way for novel screening systems that reveal pathogenic effects of breast cancer risk factors
- Why are breast organoid models useful tools for the study of both normal and diseased human mammary gland development and cell processes
- What is the current status of breast organoid research and advantages and limitations of distinct types of organoid models derived from iPSCs, primary cells, and fresh mammary tissue
- How to produce detailed characterizations of the microarchitecture of breast organoid models using spatial biology technology, such as CODEX.
Webinars will be available for unlimited on-demand viewing after live event.
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.