Date: May 25, 2021
Time: 6:00am (PDT), 9:00am (EDT), 2pm (BST), 3pm (CEST)
Therapeutic drug monitoring (TDM) of Busulfan is essential for management of Bone Marrow Transplant (BMT) patients, by optimizing dose, supporting compliance, and minimizing toxicity. Busulfan is a chemotherapeutic agent used as a component in a myeloablative preconditioning regimen before hematological stem cell transplantation. A liquid chromatography-tandem mass spectrometry method for rapid and accurate quantification of Busulfan in plasma was developed and validated in the Department of Chemistry at Baptist Hospital of Miami. The TDM and timely plasma concentration reporting of Busulfan would provide an improvement in the quality-of-care for BMT patients.
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