OCT 29, 2020 8:00 AM PDT

Cell types to targets: Single cell RNA-sequencing for drug discovery

Sponsored by: 10x Genomics
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Computational Biologist, GSK
    Biography
      Sarah Middleton completed her PhD in Genomics and Computational Biology at the University of Pennsylvania, where she studied neuron biology using single cell RNA-seq. Now a Computational Biologist at GSK, she works across disease areas doing scRNA-seq analysis to inform drug discovery and development efforts. Her recent work has also focused on improving the resolution of cell type identification to gain additional insight into the differing roles of immune cell subtypes and state changes in disease.

    Abstract
    Date:  October 29, 2020
    Time: 8:00am (PDT),  11:00am (EDT),  4:00pm (CET)
     
    What cell types cause and perpetuate disease? For many diseases, scientists only have guesses to this critical question. Single cell RNA-sequencing (scRNA-seq) presents a new opportunity to survey the full range of cells in a tissue and dissect how individual cell types change in their expression profiles, abundance, and interactions in the disease context. scRNA-seq can also reveal unexpected new subtypes or functional states related to disease.
     
    In this webinar, Dr. Sarah Middleton, Computational Biologist at GlaxoSmithKline, will discuss how taking a cell type–first approach to understanding disease can be a powerful strategy to inform multiple steps of the drug discovery pipeline, from target identification to patient stratification. A key requirement for success of this strategy is accurate and deep cell-type classification, which remains challenging, especially for subtypes. Dr. Middleton will discuss how to alleviate these challenges both through computational approaches and integration of multiomic data types. Finally, she will discuss what is needed to scale up these approaches and make full use of the huge compendiums of single cell data now becoming available.
     
    Learning Objectives
    • How scRNA-seq can be used in drug discovery and development
    • The challenges of cell subtype identification and how to address them with computational tools and multiomic data integration
    • The importance of automated analysis methods and pipelines, and pitfalls to avoid
     
     
    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

    Show Resources
    You May Also Like
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    NOV 10, 2020 7:00 AM PST
    C.E. CREDITS
    NOV 10, 2020 7:00 AM PST
    DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
    JUN 23, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 23, 2020 10:00 AM PDT
    DATE: June 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    Loading Comments...
    Show Resources
    Attendees
    • See more