NOV 09, 2021 11:00 AM PST

Chemical cytoprotection for stress-free use of human stem cells in basic and translational research

Sponsored by: Namocell
C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract
Date:  November 09, 2021
Time: 11:00am (PST),  02:00pm (EST)
 
Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term growth and functional differentiation. We recently reported the development of a new small molecule cocktail that can be used as a universal end-to-end solution for stress-free culture of human cells. This four-part small molecule cocktail, which we named CEPT (Chroman 1, Emricasan, trans-ISRIB, Polyamines), enhanced cell survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function. CEPT improved routine cell passaging, cryopreservation/thawing of pluripotent and differentiated cells, embryoid body and organoid formation, single-cell cloning, genome editing, and new iPSC line generation. Thus, CEPT represents a unique poly-pharmacological strategy for comprehensive cytoprotection, providing a new rationale for efficient and safe utilization of hPSCs. Conferring cell fitness by multi-target drug combinations may become a common approach in cryobiology, drug development, and regenerative medicine.
 
Learning Objectives
  • Discover quick and easy methods for isolating single cells for downstream applications
  • Discuss how to enhance cell survival of genetically stable human pluripotent stem cells (hPSCs)
  • Ensure safe and robust stem cell growth with a novel, four-part small molecule cocktail
 
 
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