AUG 27, 2019 8:00 AM PDT

Comprehensive Proteomics and Lipidomics Strategies to Advance Disparities Research in Alzheimer's Disease

Sponsored by: Agilent
Speaker

Abstract

DATE: August 27, 2019
TIME: 08:00 AM PDT 


Our laboratory is exploring hypotheses about how lipid metabolism contributes to racial disparities in Alzheimer’s disease using comprehensive proteomics and lipidomics mass spectrometry-based approaches. Specifically, we have developed robust quantitative assays to measure proteins in post-mortem brain, liver, and heart tissue as well as in plasma and a range of lipids and lipid classes in plasma. Combined, these analyses provide tremendous insight into lipid metabolism and many other biological pathways that are altered in the brain and periphery of Alzheimer’s disease. Furthermore, protein and lipid changes that are altered in ways that are unique to a given racial/ethnic background have been assessed. This presentation will discuss the various proteomic and lipidomics approaches established, results from pilots with small cohorts of Alzheimer’s disease patients, and the implications of these findings for understanding disease pathogenesis especially as it relates to racial/ethnic disparities in Alzheimer’s disease.
 
Learning objectives:

  • Participants will learn about the relationship between lipid metabolism and racial disparities in Alzheimer’s disease.
  • Participants will learn quantitative proteomics strategies for assessing differences in various biological tissues from diseased and control individuals.
  • Participants will learn mass spectrometry based lipidomics strategies to profile lipids in human plasma.

 

For Research Use Only. Not for use in diagnostic procedures.

 

Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

 


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AUG 27, 2019 8:00 AM PDT

Comprehensive Proteomics and Lipidomics Strategies to Advance Disparities Research in Alzheimer's Disease

Sponsored by: Agilent


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