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JAN 26, 2017 5:00 AM PST

Control-Alter-Delete: Epigenetic regulation by non-coding RNAs in neuronal systems

Speaker
  • Assistant Professor in the Department of Neurobiology at the University of Alabama
    Biography
      Jeremy Day, PhD, is an Assistant Professor in the Department of Neurobiology at the University of Alabama at Birmingham. He received his PhD from the University of North Carolina in 2009 under Regina Carelli, followed by a postdoctoral fellowship with David Sweatt at UAB.

      Jeremy joined the Neurobiology faculty at UAB in 2014, where his lab investigates the neurobiology of reward- related memory systems in the brain and the role of these circuits in motivated behaviours. His research integrates molecular, physiological, behavioral, genetic and epigenetic tools to understand how experience alters epigenetic states in the brain- with specific interest in the role of non-coding RNAs within this process.

      His ultimate goal is to manipulate epigenetic or transcriptional patterns within selected neuronal populations to achieve therapeutic outcomes from the brain diseases. His work is supported by research grants from the National Institute on Drug Abuse, the Pittman Scholars Program, and by the Evelyn McKnight Brain Institute.


    Abstract

    Thursday, January 26 | Emerging evidence suggests that non-coding RNAs can interact with epigenetic modifiers to both recruit and suppress epigenetic mechanisms, and that this functions can be regulated by activity states of neurons. Register today to join Dr Day as he highlights his recent work exploring how non-coding RNA species regulate DNA methylation in neuronal systems, including interactions between non-coding RNAs and DNA methyltransferases and genome-wide characterization of non-coding RNAs that arise from protein-coding genes , and  reviews the functional modulation of non-coding RNAs in memory formation and behavior. 


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