With the discovery of idiopathic pneumonia in December 2019 began what is now the global pandemic of COVID-19. Initially named 2019-nCoV, this disease is the clinical manifestation of a novel coronavirus first reported in Wuhan, China. Coronaviruses are not new to humans, but their recent evolution has become a threat to them. How did all this lead to the present-day situation? To understand that, this talk clearly explains the relevant variables in the equation: the science; the statistics; and the clinical profile, including management solutions and investigational agents.
1. What kind of virus is the coronavirus? Where is its greatest vulnerability and why?
2. What differentiated the HCoVs discovered in the 1960s from the SARS-CoV and MERS-CoV?
3. What are the 4 structural proteins of coronaviruses and what are their functions? Which part is responsible for host cell receptor identification? S Which anchors the viral RNA? M What is the 5th structural protein found in beta coronaviruses?