JUN 30, 2020 10:00 AM PDT

COVID-19 Serology Assays and Cell Therapy Strategies

Speakers
  • Laboratory of Dr. Florian Krammer - Department of Microbiology, Icahn School of Medicine at Mount Sinai
    BIOGRAPHY
  • Physician in the Division of Hematology and Oncology at Nationwide Children's Hospital and director of the Cellular Therapy and Cancer Immunology Program at Nationwide Children's Hospital
    BIOGRAPHY
  • Vice President Development & Operations, Pluristem Therapeutics Inc.
    BIOGRAPHY

Abstract

DATE:  June 30, 2020

TIME:   10:00 am PDT, 1:00 pm EDT

 

COVID-19 is a highly pathogenic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We have assembled a panel of experts to discuss a variety of current strategies for both serological testing and cell therapies to combat tissue damage caused by COVID-19. 
 
Part 1. Serological assays 
 
Serological assays are blood-based tests that have proven to be critical in understanding whether people have been exposed to a pathogen by looking at their immune response.  This has been particularly helpful in quantifying the number of COVID-19 cases, including those that may be asymptomatic or have recovered.  Here we describe a serological assay established by the lab of Dr. Florian Krammer of Icahn School of Medicine at Mount Sinai to detect seroconversion to SARS-CoV-2 in humans. Using this assay, we can assess if people have antibodies against the spike protein of SARS-CoV-2.  
• The assay has demonstrated high specificity and high sensitivity and has received emergency use authorization (EUA) from the Food and Drug Administration (FDA).  
• Dr. Krammer’s lab has also assessed if antibodies in human serum play a functional role, such as neutralization of the virus and have observed that high titers of antibody in human serum correlate with high neutralizing activity in vitro against live SARS-CoV-2.  
  
Part 2. Cell therapies 
 
A growing number of clinical studies are underway to investigate the roles of cell therapy, particularly using mesenchymal stem cells (MSCs) and natural killer (NK) cells, to address the damage caused by COVID-19.  

• Studies show that immunomodulatory and reparative properties of MSCs could reduce mortality rate by reversing acute inflammation of lungs, inhibiting over-activation of immune cells, protecting lung alveoli epithelial cells, promoting tissue repair, preventing pulmonary fibrosis, or improving lung function.   

• NK cell therapy may restore the quantitative and qualitative NK cell defect associated with SARS-CoV-2 and slow the progression of severe COVID-19 disease in high-risk individuals by improving direct recognition of infected cells, suppressing viral propagation, and promoting adaptive immune responses. 
 

 

Learning Objectives:

  • Understand the importance of serology testing in seeing the full impact of the COVID-19 disease in a population
  • Understand the role antibodies in human serum play in neutralizing against live SARS-CoV-2
  • Identify cell therapy strategies to combat tissue damage caused by COVID-19 disease
  • Summarize the main challenges facing clinical investigation into cell therapy for COVID-19 

 

 

Webinars will be available for unlimited on-demand viewing after live event.

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
JUN 03, 2021 12:00 PM CST
JUN 03, 2021 12:00 PM CST
DATE: June 3, 2021 TIME: 12:00pm SGT This webinar is a virtual event that focuses on utilizing the Gibco CTS Rotea System for Cell and Gene Therapy...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
Loading Comments...
Show Resources