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SEP 17, 2020 4:30 PM PDT

COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell Repertoires

Speakers
  • Distinguished Engineer
    Biography

      Sean Nolan was CTO at Adaptive from 2014 through 2019. Now as Distinguished Engineer, Sean works on specialized projects primarily supporting internal and external research at Adaptive Biotechnologies.

    • Senior Manager, Research and Business Development
      Biography

        Dr. Patrick Raber is a Senior Manager on the Research and Business Development Team and  focuses on the incorporation of immunosequencing into translational research and clinical trials for Adaptive's academic and biopharmacuetical partners.

      • VP, Research, immunoSEQ Dx
        Biography

          Dr. Thomas Snyder is VP, Research for immunoSEQ Dx at Adaptive Biotechnologies where he leads the scientific program, in collaboration with Microsoft, to map T-cell receptor sequences to the antigens they bind to in order to create diagnostics for infectious disease, autoimmune diseases, and cancer.


        Abstract

        T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of antibodies by B cells. This central role for T cells makes them a desirable target for assessing the immune response to SARS-CoV-2 infection. In partnership with Microsoft, Adaptive Biotechnologies has created a comprehensive and detailed open access database, ImmuneCODE, that provides COVID-19 data to accelerate ongoing efforts to develop better diagnostics, vaccines, and therapeutics for COVID-19. Here we will discuss the science behind the ImmuneCODE database presented in Nolan et al, some of the applications for which you can analyze the data, use of the immunoSEQ T-MAP COVID service, and initial data insights from the COVID-19 data described in Snyder et al. Research Use Only. Not for use in diagnostic procedures.

        Learning Objectives: 

        1.  A deep dive into the open-access ImmuneCODE database and the utility of the newly launched immunoSEQ T-MAP COVID service

        2. Discussion of Nolan et al. and Snyder et al. publications

        3. Initial data insights from COVID-19 data and how a blood-based molecular approach to characterizing the cellular immune response has applications in vaccine development as well as the potential to inform clinical diagnostics and monitoring


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