MAR 20, 2014 2:00 PM PDT

Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology

Presented at: Neuroscience
Speaker
  • Director Stem Cell Research Center & Core Facility, Professor, Sanford-Burnham Medical Research Inst, Faculty Physician, Department of Pediatrics, University of California, San Diego
    BIOGRAPHY

Abstract

The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in organogenesis and then to maintain homeostasis of that organ (e.g., the nervous system) in the face of perturbations. Accomplishment of these goals requires numerous actions, cell replacement representing but one. The tasks, in fact, require extensive cross-talk between multiple cell types (including stem cell-derived progeny themselves) and the unfolding of complex developmental programs. This complexity actually enriches the therapeutic potential of the stem cell.
We study the behavior of neural stem cells (NSCs) in various models of injury and degeneration. During neurodegeneration and inflammation, factors are transiently elaborated which draw NSCs (even over great distances) to engage the niche and attempt restoration of equipoise by a variety of mechanisms. These actions include differentiating towards the replacement of impaired neural cells, both neurons and non-neuronal chaperone cells, all of which are essential for restitution of function. NSCs elaborate factors that promote neuroprotection, trophic support, differentiation, neuritogenesis, connectivity, angiogenesis, inhibition of inflammation and scarring. In addition to producing diffusible factors, NSCs communicate via gap junctions to re-equilibrate the intracellular metabolism of endangered neurons. NSCs may serve as vehicles for protein delivery enabling simultaneous cell and gene therapy. NSCs synergize with biomaterials to "re-engineer" damaged regions. Multimodal approaches are likely required for most neurological conditions; NSCs may serve as the glue. When studied in vitro (development- or disease-in-a-dish), NSCs may help identify novel mechanisms, drug targets, and the drugs themselves.
While repair may entail recapitulating developmental programs, pathology (e.g., cancer) may represent the perversion of such programs. Thwarting such pathology, may involve the pharmacological re-establishment of the proper program.
These various themes will be discussed.


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
JUN 24, 2021 10:00 AM PDT
C.E. CREDITS
JUN 24, 2021 10:00 AM PDT
Date: June 24, 2021 Time: 10:00am PDT The Chan Zuckerberg Initiative (CZI) was founded to help solve some of society’s toughest challenges— from eradicating disease and improving...
JUN 03, 2021 12:00 PM CST
JUN 03, 2021 12:00 PM CST
DATE: June 3, 2021 TIME: 12:00pm SGT This webinar is a virtual event that focuses on utilizing the Gibco CTS Rotea System for Cell and Gene Therapy...
MAR 20, 2014 2:00 PM PDT

Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology

Presented at: Neuroscience

Specialty

Cognitive Neuroscience

Brain Health

Animal Models

Immunology

Brain

Brain Diseases

Gene Sequencing

Biology

Life Sciences

Dna

Neuroscience

Animal Production

Environment

Cell Culture

Molecular Genetics

Geography

North America50%

South America50%

Registration Source

Website Visitors100%

Job Title

Medical Doctor/Specialist100%

Organization

Hospital50%

Retired50%


Show Resources
Loading Comments...
Show Resources