Cryo-EM in discovery and rational engineering of biologics

Date:  July 27, 2021

Time: 9:00am PDT

During this interactive webinar you can ask questions, get answers, and engage with Dr. Yuri Iozzo from Sanofi and Dr. Dan Cannon from Schrödinger.

Dr. Yuri Iozzo presents "An integrated structural biology platform specialized for sub-100 kDa protein complexes to support biologics discovery and rational engineering". Developing a biologic drug requires successful decision making at each step of selection, optimization, and/or combination of the right candidates at early research stages. Knowing the structural information and binding pattern between drug target and discovery candidates greatly increases the possibility of success.

The cost-effective platform, to obtain fast and accurate structural information for biologics projects, allows to obtain quality results within days to weeks, including sub-100 kDa complexes, which are usually considered as a challenge due to their small size.

Dr. Dan Cannon presents "Physics-based Computational Modelling Applied to The Design and Optimization of Biologics". A common goal in the design and optimization of biologic drugs is the reliable prediction of the impact of specific residue mutations on protein stability, binding affinity, selectivity, and functional attributes that are correlated with these properties.

Free energy perturbation (FEP) offers a rigorous, physics-based approach for accurately computing free energy changes induced by protein residue mutation. FEP incorporates conformational sampling using explicit solvent molecular dynamics and a robust underlying force field for modelling interactions between atoms in the system.

Learning Objectives

• Discuss how can the cryo-EM workflow be streamlined.
• Discuss to improve the throughput in cryo-EM structure determination of biologics.
• How the FEP+ computational chemistry software platform can accelerate your research and development projects?
• Determine how to improve the accuracy of your in silico predictions with proven methodologies.

Webinars will be available for unlimited on-demand viewing after live event.

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.