JUN 13, 2023 10:00 AM PDT

Advanced digital PCR applications for cell and gene therapy research: Viral vector quantification and CAR-T cell monitoring

Sponsored by: Thermo Fisher Scientific
Speakers

Event Date & Time
Date: June 13, 2023
Time: 10:00 AM (PDT), 1:00 PM (EDT)
Abstract
Advanced digital PCR applications for cell and gene therapy research: Viral vector quantification and CAR-T cell monitoring
This event will feature two talks focusing on the cutting-edge use of digital PCR (dPCR) for research, exploring CAR-T cell monitoring in clinical research phases and high-throughput adeno-associated virus (AAV) quantification, two pivotal areas of cell and gene therapy research. 
 
CAR-T cell monitoring in clinical research phases using dPCR technologies.
Raquel Munoz Garcia, PhD
This presentation explores how dPCR enables precise and sensitive quantification of CAR-T cells and how dPCR can be utilized in research for CAR-T cell monitoring. Dr. Garcia will further explore how this technology is driving advancements in cell and gene therapy research for cancer and other diseases.
 
Achieving consistent AAV quantification with the QuantStudio Absolute Q AutoRun dPCR Suite
Himani Patel and Kimberly Gomez
Accurate quantification of AAV vectors could be crucial for quality control and timely decision-making during drug development. dPCR is a precise and reliable method for quantifying nucleic acid targets without relying on standard curves. The Applied Biosystems™ QuantStudio™ Absolute Q™ AutoRun dPCR Suite simplifies not only the workflow, but also data collection and analysis, enabling high-throughput sample processing with minimal intervention. This presentation outlines a recent study that demonstrated the consistency of dPCR data generated by this suite using an AAV assay, achieving less than 3% coefficient of variation (CV) for all nucleic acid targets within the expected concentration accuracy range. The study also highlights the promising results and importance of high throughput dPCR workflow solutions for gene therapy research and development. .
 
The QuantStudio Absolute Q dPCR System and QuantStudio Absolute Q AutoRun dPCR Suite are for Research Use Only and are not to be used in diagnostic procedures.
 
Learning objectives:
  1. Understand the impact of using digital PCR technology for cell and gene therapy research and development
  2. Describe how digital PCR can be leveraged for accurate quantification of nucleic acid targets
 
Webinars will be available for unlimited on-demand viewing after live event.
 
 

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